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 | | Ionic Channels of Excitable Membranes by Bertil Hille ISBN-10: 9780878933235 ISBN-10: 0-87893-323-9 ISBN-13: 9780878933235 ISBN-13: 978-0-87893-323-5 Hardcover 1992-01 Sinauer Associates Find Lowest Price |
Editorials | ||
Product Description This new, fully revised and expanded edition of "Ionic Channels of Excitable Membranes" includes new chapters on fast chemical synapses, modulation through G protein coupled receptors and second messenger systems, molecules cloning, site directed mutagenesis, and cell biology. It begins with the classical biophysical work of Hodgkin and Huxley and then weaves a description of the known ionic channels together with their biological functions. The book continues by developing the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. "Ionic Channels of Excitable Membranes" is written to be accessible and interesting to biological and physical scientists of all kinds. | ||
Reviews | ||
Great text book Hille's book on ion channels of excitable membranes provides great instruction regarding the biophysics of channel function. The topics range from discussions of gating, selectivity, etc. The chapters regarding channel function were the most useful | ||
for the brain child I got this book for a class and never used actually used it. The book is really hard to understand and over the top. Be warned if you don't have a strong background in biophysics and other sciences this book will make no sense. | ||
The bane of my spring semester Although this book is very thorough when it comes to 'ion channels of excitable membranes,' it's essentially a 1000-page literature review. That's fine if you're an expert in the field (i.e. college professor), but for an undergraduate, it contained an overwhelming amount of information, including calculus-based math. Sometimes, it was helpful to consult when my class notes were incomplete. Otherwise, reading the assigned chapters in this book proved a waste of time. | ||
Excellent and useful text. This text is an encyclopedia of information from kinetics to structure to interactions. It's got a reserved space on my academic bookshelf. | ||
Destined to become an Oprah Book Club selection Some books have opening sentences that grab you in an instant. "Call me Ishmael." "It was the best of times, it was the worst of times." And now, Hille joins the list of authors to reach out and grab us, with the awe-inspiring "Ion channels are macromolecular pores in cell membranes." Even after my fifth reading, that line still gives me the shivers. But it takes more than a brilliant opening to make a great book, and Hille delivers. From a distinctly jaunty derivation of the Nernst equation to the page-turning thrills of non-stationary fluctuation analysis, the book is hard to put down. It does bog down a little in Chapter 10, "Elementary Properties of Ions in Solution"--after all, is there anyone who isn't already aware of the fundamentals of electrodiffusion? But this is really a minor trifle in an otherwise masterful work. It's just a matter of time before Oprah gives this book a nod; buy it now and avoid the rush! | ||